Pharmaceutical PVC hard sheets are rigid thin sheets made from polyvinyl chloride (PVC) as the main raw material through special processing techniques, and they are mainly used for pharmaceutical packaging. The specific and detailed description of them are as follows:

Core Features

1) Safety Priority: Raw materials and additives (such as stabilizers and lubricants) are all pharmaceutical-grade, complying with the Chinese Pharmacopoeia and relevant standards for pharmaceutical packaging materials. They are non-toxic, odorless, and do not react chemically with drugs, ensuring drug purity.

2) Functional Adaptability: It combines certain barrier properties, mechanical strength, and transparency. It can protect drugs from external environmental influences while facilitating observation and use.

3) Processing Compatibility: Easy to heat-seal, print labels (e.g., drug name, batch number, expiration date), and can be combined with materials like aluminum foil to form blister packaging, meeting the needs of automated packaging production lines.

Production Process

1) Raw Material Proportioning: Using polyvinyl chloride resin as the base material, pharmaceutical-grade plasticizers (e.g., phthalates, with strict dosage control), heat stabilizers (e.g., calcium-zinc composite stabilizers, replacing toxic lead salt stabilizers), lubricants (e.g., stearic acid), etc., are added in proportion to ensure component safety and meet processing requirements.

2) Mixing and Plasticizing: The proportioned raw materials are put into a high-speed mixer for uniform stirring, then heated and melted into a homogeneous melt through an extruder or internal mixer.

3) Forming Processing: Formed by calendering or extrusion—calendering uses multi-roll calenders to press the melt into thin sheets of uniform thickness; extrusion uses a T-die to extrude the melt, which is then shaped by cooling rolls to form hard sheets.

4) Post-Processing: Cut into rolls or sheets as needed, and packaged after inspection (e.g., appearance, thickness, hygiene indicators) to ensure qualification.

Common Specifications

1) Thickness: Usually 0.20mm~0.30mm, adjusted according to drug packaging needs (e.g., 0.25mm for tablet packaging, slightly thicker for capsules to enhance stiffness).

2)  Width: Roll width is mostly 300mm~1200mm; sheet sizes can be customized (e.g., 1000mm×1200mm) to fit different specifications of blister packaging production lines.

3)  Appearance: Flat surface, free of bubbles, impurities, or scratches, with transparency ≥85% (ensuring clear observation of the shape and color of drugs inside).

Key Performance Indicators

1) Barrier Properties: It has specific requirements for water vapor transmission rate (WVTR) and oxygen transmission rate (OTR). Typically, the water vapor transmission rate is ≤15g/(m²·24h) (under 38℃, 90% RH conditions), reducing the risk of drug moisture absorption and oxidative deterioration.

2) Mechanical Properties:

- Tensile strength: ≥40MPa in the longitudinal direction and ≥35MPa in the transverse direction, ensuring the packaging is not easily torn during transportation and storage.

- Stiffness: Has a certain hardness to maintain the shape of blisters and prevent drug damage from pressure.

3) Heat-Sealing Performance: When heat-sealed with aluminum foil, the heat-sealing strength is ≥1.0N/15mm, ensuring tight sealing and preventing drug moisture or leakage.

4) Temperature Resistance: Stable within the range of -10℃~60℃, adapting to conventional storage environments and avoiding low-temperature embrittlement or high-temperature deformation.

Main Applications

1) Core Application: As the "base material" for blister packaging, it is combined with pharmaceutical aluminum foil (as the lid material) for packaging solid drugs such as tablets and capsules. It forms blister units, each containing a certain number of drugs, facilitating access and counting.

2) Other Scenarios: Occasionally used for shallow tray packaging or lining packaging of small-dose solid drugs, but its main application remains in blister packaging. It is one of the most commonly used packaging materials for oral solid preparations, effectively extending drug shelf life and ensuring medication safety.

All parameters of pharmaceutical PVC hard sheets must pass strict inspections (e.g., heavy metal content, dissolution tests) to meet the high safety requirements of pharmaceutical packaging, making them an important part of the drug quality assurance system.